Protagonist Therapeutics Delivers Positive Topline Results in Psoriasis Study

Protagonist Therapeutics, Inc. (Nasdaq: PTGX) has received positive topline results in its Phase 2b FRONTIER 1 clinical trial evaluating a treatment for psoriasis. The study is being conducted in collaboration with Janssen Biotech, Inc.

The company’s candidate, JNJ-2113, is an oral Interleukin-23 receptor (IL-23R) antagonist peptide. IL-23 inhibitors can help limit the inflammation that causes psoriasis symptoms.

Highlights

  •  Data from the 255-patient FRONTIER 1 Phase 2b study showed that a statistically significant proportion of patients who received JNJ-2113 achieved a 75% improvement in skin lesions.
  • A clear dose response was observed across an eight-fold dose range.
  • JNJ-2113 was well-tolerated with no adverse events.
  • The company’s SUMMIT Phase 2a trial is testing a delayed release JNJ-2113 tablet versus placebo in adults with moderate to severe plaque psoriasis.
  • Advancement of JNJ-2113 into a Phase 3 study and meeting the primary endpoint in that study would qualify Protagonist for milestone payments of $50 million and $115 million, respectively.
  • Protagonist remains eligible for up to $855 million in various milestone payments and tiered royalties based on worldwide net drug sales.

Data from various pre-clinical and clinical studies on JNJ-2113 will be presented at medical conferences beginning in the second quarter of 2023.

JNJ-2113 is being developed through a license and collaboration agreement between Protagonist and Janssen Biotech, Inc., one of the Janssen Pharmaceutical Companies of Johnson & Johnson.

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Protagonist Therapeutics Delivers Positive Topline Results in Psoriasis Study

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